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Abstract
The GH501 study developed a specific LC-MS/MS method to evaluate the preclinical pharmacokinetics in rats. The study found that GH501 had slow absorption and elimination, moderate distribution throughout the body, and a relatively high clearance rate. The AUC value suggested that the total amount of drug exposure in the body was moderate. These parameters can provide vital information for drug dosing and therapeutic monitoring for future studies. The Cefepime study investigated drug pharmacokinetics in 12 critically ill patients with sepsis or sepsis shock. It found that cefepime quickly reached its maximum concentration in the bloodstream, was well-distributed, and rapidly eliminated in critically ill patients. The study also found no significant difference in pharmacokinetic parameters between critically ill patients and healthy adults.