Early diagnoses and targeted therapies are the crux of successful patient care for almost every cancer. Within this work, we explore various facets of this by studying tu[...]

The family Nairoviridae consists of a group of tick-borne viruses in the order Bunyavirales. Several nairoviruses have been demonstrated to cause human disease, the most [...]

The intentional use of organophosphate (OP) nerve agents and pesticides pose a significant health threat through their inhibition of human acetylcholinesterase (hAChE), w[...]

P-glycoprotein (Pgp) is an efflux transporter that is a member of the ATP binding cassette (ABC) superfamily. The transporter is found on the apical surface of cells and [...]

RNA interference (RNAi) molecules have become a powerful drug development platform and are critical tools in molecular biology. They harness the endogenous RNAi defense [...]

Atypical Actives play a significant role in the manufacturing of over-the-counter (OTC) and prescription (Rx) drugs. The FDA expects manufacturers of Atypical Actives to [...]

Hydrodynamic gene delivery was developed as an efficient and safe method for gene transfer into hepatocytes in mice via tail vein injection. The method then evolved into [...]

Because of excessive energy intake and lack of sufficient physical activity, obesity prevalence has been increasing worldwide. In the United States, more than a third of [...]

G-Protein coupled receptors (GPCRs) mediate a wide array of cellular functions, such as cell proliferation, migration, and survival. Regulators of G-protein signaling (RG[...]

The LysR-type transcriptional regulator (LTTR) BenM is involved in controlling benzoate degradation in the soil bacterium Acinetobacter baylyi strain ADP1. The 1.8 resol[...]

Tumor microenvironment plays an essential role in tumor growth and drug resistance. Accumulated evidence during recent years suggest the existence of environmental hetero[...]

Pseudomonas aeruginosa is an important public health pathogen that is well-known for its high ability to adapt to a diverse range of environmental conditions, including t[...]

The pharmacokinetics of a hypothetical prodrug of a cytosine analogue, and the stereoselective and allometric scaling of the pharmacokinetics of a cytidine analogue are i[...]

The number of small oligonucleotides being used to improve human health is increasing rapidly. There are currently four FDA-approved therapeutic oligonucleotides and smal[...]

Muscadine skins and seeds of two varieties were analyzed for total phenolic content and antioxidant ability. Extracts were then screened for abilities to directly inhibit[...]

Although the blood and tissue partition coefficients (PCs) for pyrethroids in adult rats have previously been published, no one has evaluated the influence of maturation [...]

Malaria, particularly that caused by Plasmodium falciparum, remains one of the most deadly infectious diseases worldwide. Unfortunately, multidrug resistance (MDR) to cur[...]

Cellular signaling pathways are involved in numerous physiological processes such as reproduction, growth, and the development of cancer and chemoresistance. G-protein c[...]

Microglia are immune cells that reside in the central nervous system and are essential in innate immunity, homeostasis, and development of the central nervous system. How[...]

The work presented herein illustrates the multifaceted role of mitochondria in the survival of different in vitro disease and developmental models, including melanoma can[...]

The overall goals of this dissertation were to exploit differences in tumor microenvironment, develop dosing schedules to facilitate optimization of nanoparticulate drug-[...]

The study aims at developing a chitosan film bandage with physical attributes equivalent or better than the predicate Bandage and to further optimize the bandage quality [...]

The viewpoints and methodologies of pharmacokinetic modeling in toxicology and pharmaceutics are divergent. In order to appreciate both approaches, each method was used t[...]

The treatment of HIV/AIDS is one of, if not, the most challenging medical enigmas of the 20th and 21st centuries. At the time of its discovery, HIV patients were predomi[...]