College of Pharmacy

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder resulting in the loss of dopamine-producing neurons in the substantia nigra, leading to motor dysfunc[...]

Diagnosis and prognosis of acute respiratory distress syndrome (ARDS) depend on clinical criteria that are confounded by ARDS heterogeneity. Clinical diagnostics miss 40%[...]

Multidrug resistance (MDR) is a primary barrier to successful cancer treatment with small molecule drugs. One mechanism of resistance is through transporters which pump d[...]

P-glycoprotein (Pgp) pumps structurally different substrates out of cells, which leads to decreased intracellular drug concentration. Taxane drugs represent a class of an[...]

Despite the central role of mitogen-activated protein kinase (MAPK) p38 in driving pathological inflammation - including during pulmonary injury - effective therapeutic t[...]

Various advanced drug delivery systems such as lipoprotein, red blood cell, and albumin have been investigated to overcome the limitation of the conventional systems. One[...]

Multidrug therapy has become the standard treatment of acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV). Nucleoside reverse tran[...]

Several methods for removing samples from finished semisolid dosage forms are in current use. Sampling methods for semisolids vary among industry, but no standard method [...]

This dissertation is divided into two parts entitled I. Trace Level Determination of Trichloroethylene from Liver, Lung, and Kidney Tissues by Gas Chromatography/Mass Spe[...]

Aqueous solubility is an important pmualraatmieotne dr ievne flooprment studies of oral dosage forms as it is a determinant of oyr. Ialb bupiroaovfaeinl (abIiBl)i, wt hic[...]

Iron deficiency anemia (IDA) is the most common nutritional deficiency in the world and intestinal parasites are estimated to be responsible for 30-57% of IDA cases (Yip [...]

Numerous experimental, epidemiological and clinical trails have suggested non-steroidal anti-inflammatory drug(NSAID) usage potentially reduces the risk of developing ca[...]

The pharmaceutical industry is presently facing a challenge in projecting itself as a credible corporate citizen. Recognizing the effectiveness of celebrities in other pr[...]

Ribosomal frameshifting is a translational mechanism commonly exploited by RNA viruses in an effort to overcome the constraints of their limited genome size. Frameshift[...]

Malignant glioma represents a very difficult therapeutic challenge. One new therapeutic strategy is gene therapy, which involves the delivery to and expression of the the[...]

Asthma is a chronic pediatric disease characterized by inflammation of the airways. The objectives of this study were to explore risk factors for asthma incidence, estim[...]

The stability of 10mg/mL zidovudine and either 12.5mg/mL dobutamine or 25 mg/L ranitidine hydrochloride stored in 0.9% sodium chloride and 5 % dextrose injections in 50 c[...]

In the first part of the dissertation, the formulation and development of an artificial lipoprotein gene delivery system is discussed. Cancer cells have a higher requirem[...]

Genetic diversity was studied in cattail populations (Typha angustifolia and T. latifolia) from areas around Chornobyl, site of a nuclear accident, and other locations in[...]

Non-adherence is a public health problem costing over $100 billion/year. Patients lack of belief in the medication benefits and lack of information about the drug are im[...]

Ibuprofen was encapsulated with beeswax by the hydrophobic congealable disperse phase method. Incorporation of stearyl alcohol in the formulation decreased the average si[...]

Consumers, as patients want to play a more active role in their healthcare. The growth in direct-to-consumer (DTC) advertising of prescription drugs has increased consume[...]

A programmed 1 frameshift in the HIV-1 protease gene has been previously demonstrated. The sequence encoded in the overlapping 1 reading frame, named pro-fs, has signific[...]