Alterations in lipid profiles have been shown in patients with COPD, but the underlying molecular mechanisms remain unclear. In this study, we aim to investigate the role[...]

Diabetes mellitus (DM) is a common comorbidity in acute lung injury (ALI) patients. Despite its well-established prevalence and known complications affecting many organs,[...]

Idiopathic pulmonary fibrosis (IPF) is an incurable, chronic and progressive lung disease with severely poor prognosis. The presence of pulmonary hypertension (PH) second[...]

Achieving therapeutic angiogenesis remains an unrealized goal in cardiovascular diseases. We have previously shown that while low levels of peroxynitrite are required to [...]

Despite the reduced incidence and improved 5-year survival rate of localized PCa patients, there is a marked increase in the incidence of metastatic PCa (mPCa) and associ[...]

Endothelial to mesenchymal transition (EndMT) and myofibroblast differentiation (FibroMF) occur in embryogenesis and adult pathologies such as the organ fibrosis. Stromel[...]

Prostate Cancer (PCa) is the second leading cause of cancer related deaths among men in the United States. Transforming growth factor (TGF) is a pleiotropic cytokine inv[...]

Problematic alcohol use is a prevalent behavioral health issue among college students. Evidence indicates that problematic alcohol use and other mental health problems ar[...]

Post-stroke cognitive impairment (PSCI) occurs in up to 48% of patients, is animportant contributor to long-term disability. Hypertension is a major risk factor forPSCI. [...]

Background: In the United States, the opioid crisis has been considered a major public health concern. In 2015, approximately 11.5 million U.S. citizens reported misusing[...]

Despite significant improvement in our understanding of stroke pathophysiology and management, it is still a leading cause of death and disability worldwide. Intervention[...]

Prostate cancer is a leading killer in the United States. Lack of understanding of mechanisms of disease proliferation, progression and metastasis is a major hindrance in[...]

The two most important risk factors for development and progression of cognitive impairment and dementia, including both vascular cognitive impairment (VCI) and Alzheimer[...]

Acute Respiratory Distress Syndrome (ARDS) is a fatal illness with high mortality rate of around 40% and is characterized by increased pulmonary vascular permeability res[...]

Utilization of prescription drug coupon offers in Direct-To-Consumer (DTC) advertising is a recent strategy adopted by the pharmaceutical industry. Pharmaceutical compani[...]

Substance dependence is a major epidemic in the United States. There is a need for getting those with substance dependence issues into treatment, as well as retaining pat[...]

Diabetic retinopathy (DR) is a leading cause of blindness in US adults. DR starts with an early vaso-regressive stage of non-proliferative diabetic retinopathy (NPDR), wh[...]

BACKGROUND: Matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) are increased in the brain after experimental ischemic stroke in rats. These two proteases are involved wi[...]

Neointimal hyperplasia is a major event in atherosclerosis and restenosis after angioplasty. It is attributable, in part, to exaggerated proliferation of vascular smooth [...]

Venous thromboembolism (VTE) results in a tremendous health economic burden. Objectives: To determine if there is a significant association between: 1) hospital census re[...]

Objective: Increased detection of clinically insignificant prostate cancer with routinely used diagnostic tests, as well as uncertainties in the available treatments to m[...]

We previously reported enhanced cerebrovascular remodeling and arteriogenesis in experimental type 2 diabetes. This study tested the hypotheses: 1) cerebral but not perip[...]

Diabetes leads to restructuring of vascular extracellular matrix components, resulting in increased media-to-lumen (M/L) ratios, decreased vascular compliance, and decrea[...]

Stroke remains to be a major health problem and one of the most common and undertreated disorders worldwide. With the limited treatment options, recovery is limited to th[...]

Endothelial-to-mesenchymal transition (EndMT) is greatly implicated in various cardiopulmonary diseases. Although TGF has been shown to be involved in inducing EndMT, its[...]