These studies investigated the impact of application variables i.e. ground speed, carrier volume, and droplet size on pesticide spray deposition, quality, canopy penetration, and efficacy in peanut. Increasing ground speed significantly reduced deposition and impacted spray quality for the conventional sprayer without a rate controller whereas utilizing a rate controller resulted in more consistent spray deposition and quality. Both carrier volume and droplet size influenced spray deposition, droplet density, and canopy penetration in peanut. The higher carrier volumes of 140 to 187 L ha-1 and medium to coarse spray droplets increased droplet density, thereby improving spray deposition for both herbicide and fungicide applications in peanut. They enhanced deposition up to the middle of peanut canopies, while deposition at bottom remained consistent regardless of carrier volumes and droplet sizes. The higher carrier volume and medium droplet showed improved disease control in some cases but neither variable affected weed control and yield.