Metastasis to bone occurs in approximately 70% of patients with advanced breast cancer, and in most cases treatment will not be successful. In 2024, it is expected that within the U.S. alone there will be 313,510 new cases of breast cancer resulting in 42,780 deaths. Current understanding of the specific biological mechanisms of bone metastasis is incomplete. Two-dimensional in vitro models of bone cancer are too simple to elucidate these mechanisms while in vivo models may be too complex to study specific protein roles or cell-cell interactions. This work focuses on the development and characterization of a tissue engineered 3D model of human bone. It is hoped that by using a commercially available 3D printer, this work will provide a process for developing effective models of the human bone niche that will be used to increase our understanding of breast cancer metastasis to bone and inform the development of improved treatments.