Mission 66, a ten-year program intended to improve conditions in Americas national parks, had a tremendous impact on the National Park Service. Many of the resources dating to the program are now considered historic; many more will become eligible within the decade. This thesis examines the methods and messages currently used by the National Park Service to interpret Mission 66 and Mission 66 resources and the challenges presented when interpreting the program and its resources. Interpretation is an important mechanism used by the National Park Service to inspire and educate visitors about their resources and management practices; interpretation also serves as an important tool to improve stewardship of park resources and encourage civic engagement. In light of the Mission 66 programs historic status, the thesis also presents opportunities to interpret the iconic program that will increase public awareness and stewardship of these important park resources.