Several methods for removing samples from finished semisolid dosage forms are in current use. Sampling methods for semisolids vary among industry, but no standard method exists. These methods are tailored to specific formulations and manufacturers. This creates the possibility for differences in the determination of in vitro release specification, batch variability and stability profiles. The present study evaluates a standard method that will minimize variability in sampling, which will enhance the performance testing of semisolids.