In this study, by analyzing the RNAseq data of 25 canine colon tumor and normal samples, we want to further explore the potentiality of canine colorectal cancer as a model of human colorectal cancer. The colon cancer samples were separated into 3 groups based on PCA analysis. By integrating the histology data and PCA analysis results, the three groups are two different groups of carcinomas and one normal group. The DEseq analysis shows that, one of the carcinoma groups has highly regulated cell cycle signaling and the other carcinoma group has highly regulated immune-response signaling. They also have different residential bacteria. Future work can be done to analyze genetic alterations of these two groups and then compare to the human study of hypermutated and non-hypermutated carcinomas. A gene named C1orf63 which is related to cell proliferation is also studied.
