Although S. pneumoniae (Spn) has been investigated for over a century, it is still a major human pathogen that causes a variety of invasive pneumococcal diseases (IPDs) s[...]

The fundamental issue addressed by this research is how and why do organisms choose to use Mo or W at the catalytic sites of key enzymes. The model organism is the hyper[...]

Marine phytoplankton fix carbon dioxide during photosynthesis and contribute half of the carbon fixation occurring on Earth. During photosynthesis, small organic molecule[...]

The members of the NR4A family of nuclear hormone receptors, NR4A1-3, play important albeit redundant roles in maintaining adult hematopoietic stem cell quiescence and va[...]

Bordetella species contain highly contagious respiratory pathogens, including the human pathogen B. pertussis that causes whooping cough and B. bronchiseptica that causes[...]

The addition of carbohydrate structures (glycans) to proteins is an essential post-translational modification that begins in the endoplasmic reticulum and is completed th[...]

Pectin is a family of structurally complex polysaccharides defined by the presence of -1,4-linked galacturonic acid (GalA) residues. It is present in all plant cell wall[...]

Human pluripotent stem cells (hPSCs) are powerful tools to aid in the interrogation of the mechanisms of pathology of developmental disorders as well as modeling the deve[...]

FCP1 (TFIIF-associated C-terminal domain phosphatase) is the first identified phosphatase specific for the carboxyl-terminal domain (CTD) of RNA polymerase II (RNAPII). F[...]

Lysosomal hydrolases are targeted to lysosomes by a carbohydrate-dependent mechanism. Following protein synthesis, mannose-6-phosphate (M6P) tags are added to N-glycans o[...]

Homogalacturonan (HG) is a pectic glycan in the plant cell wall that contributes to plant growth and development, cell wall structure and function, and interacts with oth[...]

The M16A peptidase subfamily comprises a group of zinc-dependent enzymes that are highly conserved among both prokaryotic and eukaryotic organisms. In this study, we have[...]

Retrotransposons are mobile genetic elements that replicate via an RNA intermediate and are similar to retroviruses. The long terminal repeat retrotransposon Ty1 is the m[...]

Telomerase is the enzyme responsible for synthesizing the repetitive DNA of telomeres. In most human tissues, telomerase activity is confined to prenatal development. How[...]

The gene encoding the protein 1-aminocyclopropane-1-carboxylate synthase (ACC synthase) has been extensively studied in plant species because of its role in regulating th[...]

The endopolygalacturonase II enzyme from A. niger was studied with an octameric fragment of -1,4-D-polygalacturonic acid. We present an approach to modeling the compl[...]

The mannose-6-phosphate (Man-6-P) targeting pathway represents one of the best-studied examples of the ability of carbohydrates to carry information. Acid hydrolases tha[...]

The initial goal of this research was to determine whether Cry1Ac and Cry1Fa -endotoxins from the insecticidal bacterium Bacillus thuringiensis (Bt) shared binding prote[...]

Cdc37 is a protein kinase-specific chaperone that either acts by itself or in concert with Hsp90. Cdc37 is phosphorylated by the evolutionarily conserved, ubiquitously di[...]

Glycosylation is a carbohydrate-based post-translational modification attached to proteins and lipids to alter their functional properties and increase structural diversi[...]

My work has focused on understanding the biological function and the molecularmechanism of SF-1, a novel chromatin boundary from the Scr-ftz region in the DrosophilaAnten[...]

Self-renewal of murine embryonic stem cells (mESCs) is controlled through the activity of leukemia inhibitory factor (LIF) by a mechanism requiring the activation of STAT[...]

Trypanosomatids, including the human infectious parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania possess a unique DNA modification in their genomes. This DN[...]

The goals of this research were to develop whole genome microarray technology for the hyperthermophilic archaeon, Pyrococcus furiosus, and to use this approach to a) eval[...]

Nitrogen fixation is a biological process essential to life. Atmospheric nitrogen (N2) must be converted to an available form such as ammonia (NH3) so that nitrogen is av[...]