Urban areas are particularly vulnerable to flood hazards due to impervious surfaces altering the runoff response and socio-economic pressures increasing the number of individuals residing in areas at risk for flooding. Despite the rich body of literature that has focused on urban flood hazards, the physical and social dimensions of this vulnerability are frequently analyzed independently of one another. This dissertation utilized a holistic and integrative human-environment interactions framework to simultaneously assess both the physical and social factors that enhanced urban flooding vulnerability throughout the Charlanta megaregion. Analyzing the entire megaregion enabled an assessment of how consistent these factors were across a variety of metropolitan areas. Developing a better understanding of the physio-social dimensions of urban flooding vulnerability is imperative to ensure the future sustainability of cities because urban population growth is projected to continue, and cities will be subjected to increased precipitation intensity due to climate change.