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Abstract

Microtubules are polymers made of the protein tubulin and play a significant role in various cell functions as they are present in the cytoskeleton of most eukaryotic cells. They have a highly dynamic structure and are formed by the self assembly of the protein tubulin, with the aid of different microtubule associated proteins. Self-assembly is the formation of an organized structure from a series of processes. In this thesis, we seek to observe the formation of a pattern when spherical units which are assumed as tubulins are excited externally by an electrodynamic exciter. The angles of contact which are determined from these experimental results are compared with simulations in virtual reality using a game engine software called Unity. We perform a mechanical structural analysis on the protofilaments, based on the configurations derived from experiments, and study the relationship between different stresses and strains and also, study the variation of stresses relative to the curvature in the protofilament. The mode shapes of these protofilaments are also studied by performing a free-free modal vibrational analysis.

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