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Abstract
Understanding the complex folding patterns on cerebral cortex has been of great interest and importance. As a typical brain anatomical pattern on gyri, 3-hinge gyral joint introduces a novel way to analyze cortical folding patterns in terms of gyral hinge numbers. In fact, 3-hinges are of unique structural and functional importance in terms of structural and functional features, brain development and brain evolution and has the potential to determine inter-subject or even inter-species correspondence. A variety of recent studies have demonstrated the distinct anatomical characteristics of 3-hinge gyral joints compared to other gyral regions, like its thicker cortices and it has more diverse connected fibers end orientations. However, the mechanism of 3-hinge gyri formation and its potentially different functional role have been rarely explored so far. To bridge this gap, I did some relevant studies from both structural and functional perspective to better understand the formation mechanism and the potential functional characteristic of 3-hinge gyri.