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Abstract
This study explored the genetic basis of impulsive personality traits, defined as performance on the Barratt Impulsiveness Scale, Version 11 (BIS-11) and the UPPS-P Impulsive Behavior Scale (UPPS-P), using a prioritized subset approach in a sample of 983 healthy young adults of European ancestry. The study used multivariate analysis to assess the relationship between impulsive personality traits and: 1) 21 a priori single nucleotide polymorphisms previously associated with impulsive personality traits; 2) 13,337 high-value addiction (HVA) markers (from the SmokeScreen array); and 3) ~5M genome-wide loci. This study identified a significant relationship between impulsive personality traits and two previously identified candidate loci (rs6313 and rs6311), both within the 5-HT2a receptor gene (HTR2a). Follow-up analyses suggested that the effects were specific to the BIS-11 Motor and Non-planning subscales. Analyses of the HVA loci and genome-wide loci yielded no statistically significant findings, but suggestive associations were present for loci in BIK, STOX2, ITGB1, and LMNTD1. This study further implicates loci within HTR2a with self-reported impulsive personality traits for future replication and identified suggestive loci from the HVA and genome-wide analyses.