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Abstract
Jet propellant 8 (JP-8) is a complex mix of hydrocarbons used by NATO (North Atlantic Treaty Organization) countries in military aircrafts and vehicles. The exposure of civilians as well as servicemen is of great importance. JP-8 contains many components that have shown to be related to many ill effects including: benzene (leukemia), naphthalene (cataract, laryngeal carcinoma, neoplasms), and long chain hydrocarbons have been shown to increase the carcinogenicity of other compoundspresent in JP-8 related to the incidence of lung cancer). The analysis of this fuel is a very arduous task because its composition varies from batch to batch and contains thousands of components. Therefore accurate identification of the compounds present in this fuel along with an accurate, sensitive and precise analytical method are needed to improve the efforts to develop a PB/PK model for this fuel. A PB/PK model will be effective in describing and predicting plasma and tissue concentrations of JP-8 andmany of its components in rodents and humans. Chapter 1 reviews methods currently in the literature for the analysis of JP-8 hydrocarbons and petroleum. The identification of compounds present in JP-8, including the best sampling methods for the three phases of JP-8 are presented in Chapter 2. The validation of an analytical method for a representative mix of JP-8 in blood and liver matrices is included in Chapter 3.