The FRiND model: a mathematical model for representing immunological interactions in muscular dystrophy pathogenesis

Muscular dystrophy (MD) describes generalized progressive muscular weakness due to the wasting of muscle fibers. The progression of the disease is affected by known immunological and mechanical factors, and possibly other unknown mechanisms. These dynamics have begun to be elucidated in the last two decades, and mathematical models have been created to understand these dynamics. This dissertation introduces a new mathematical model, the FRiND model. This model describes how the immune system repairs muscle tissue. The FRiND model will be mathematical analyzed and results verified by biological studies in the literature. This model could be the foundation for further understanding of immunological muscle repair.