Helium nanodroplets were used as a host to isolate mixed (HCl)m(H2O)n and Ne-(H2O)n clusters. These clusters were probed with infrared (IR) laser spectroscopy. For (HCl)m(H2O)n clusters the H-Cl stretch region is probed and vibrational bands are definitively assigned to the structures responsible for them through the use of pick-up cell (PUC) dependence studies, optically selective mass spectrometry (OSMS), vibrational transition moment angle (VTMA) measurement, and comparisons with theoretical predictions. In a similar manner, a new higher energy small water cluster has been observed and characterized spectroscopically. This new observation of a theoretically predicted structure of water was seen by adding a Ne atom to the nanodroplet prior to the pick-up of water.