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Abstract
The B-SNIP consortium proposed “Biotypes,” subgroups of neuro-cognitively homologous psychosis cases. Neural/intrinsic activity (IA) unbound to stimulus-processing was important for differentiating Biotypes; high non-specific activity characterized Biotype-2. Initial Biotypes characterization did not include precise estimates of IA. This report hypothesizes IA is critical for differentiating psychosis Biotypes. Method: Recruitment included psychotic probands (schizophrenia, schizoaffective disorder, bipolar-I disorder), first-degree biological relatives, and healthy persons (N=1338). Probands were also sub-grouped by Biotype. IA was quantified using 64-sensor EEG during 10-sec inter-stimulus-intervals from an auditory paired-stimuli task. Frequency bands (delta/theta, alpha, beta, gamma), single-trial power, and connectivity were quantified. Results: Biotype-1 exhibited low and Biotype 2 exhibited high IA relative to HC. No difference in DSM groups vs. HC emerged. Discussion: Only Biotypes were differentiated by IA; Accentuation of IA characterized Biotype-2. Neurobiologically-defined subgroups may facilitate use of IA in translation models aimed at developing effective treatments for psychosis-relevant neural deviations.