Weed control is essential for viable profits for production agriculture including row crops, vegetables, and perennial crops. The extent of residual and contact herbicide persistence in Georgia soils and on plastic mulch has not been fully evaluated in the literature and requires further research to better understand their long-term effects. Research was conducted to evaluate indaziflam and flumioxazin soil dissipation over time from pecan groves, determine the thermal stability and activation energy of indaziflam and flumioxazin, and determine the concentration of glyphosate, glufosinate, halosulfuron-methyl, S-metolachlor, and acetochlor wash-off within the transplant hole using a simulated vegetable bed. This research will help determine the best production practices that correspond to the dissipation of each herbicide for Georgia producers. Indaziflam and flumioxazin half-life was equivalent to 78-96 d and 27 d in Georgia pecan. Both herbicides were determined to have a groundwater ubiquity score that indicated a low leachability potential. Sorption of indaziflam increased with increasing clay content. Indaziflam degradation increased with increasing activity or size of the soil microbial population. There was an inverse correlation between flumioxazin concentration in soil, rainfall, and solar radiation. There was no direct correlation between flumioxazin concentration and soil temperature. Indaziflam and flumioxazin displayed varying kinetic behavior in aqueous solution. Temperature did not influence indaziflam stability. Flumioxazin was determined to have an activation energy of 58.4 (± 1.2) kJ mol-1. Using a simulated vegetable bed covered with TIF, after irrigating 0.63-cm less than 2% of halosulfuron, glufosinate, and glyphosate remained on the surface of the plastic mulch. In contrast, 91% and 15% of acetochlor remained on the mulch while S-metolachlor remained on the mulch at 17% and 3% after 0.63-cm and 1.27-cm irrigation volumes. All herbicide concentration was detected below 1.0 mg ai or ae in the transplant hole area despite irrigation amount. However, for halosulfuron, glyphosate, and glufosinate, these concentrations were equal to a 1.3X-8.9X field rate washing into the transplant hole. Acetochlor and S-metolachlor concentrations in the transplant hole were equivalent to 0.1X-0.7X field rates, respectively. The order of concentration detected in the transplant hole area was directly related to water-solubility.