A multi-proxy record from U-Th dated Stalagmite MAT-12 from Matupi Cave (1.19°N, 30.01°E) in northeastern Democratic Republic of Congo provides a reconstruction of the paleoenvironmental effects of the African Humid Period (AHP) in central equatorial Africa. Results from stable isotope analysis (δ13C, δ18O) and petrographic analysis (mineralogy, layer specific width, and layer-bounding surfaces) are paired with a high-resolution radiometric U-Th age model to reveal the local response to the AHP, a climate event of the late Pleistocene to mid-Holocene, 14,800 to 5500 yr BP. Though the 1300-year record from Stalagmite MAT-12 is somewhat brief and only covers a portion of the AHP, it provides a detailed reconstruction of changes in vegetation and rainfall near Matupi Cave while Stalagmite MAT-12 was deposited. This reconstruction makes notable contributions to the current understanding of the geographic extent, timing, and causes of the AHP in central equatorial Africa.