Tomato spotted wilt orthotospovirus (TSWV) is an orthothospovirus causing spotted wilt disease in peanut, which is a major yield-limiting factor in peanut production in the United States. The predominant vector in the Southeast is Frankliniella fusca (Hinds), which is also a direct pest of peanut causing severe feeding injury on seedling foliage. While TSWV field-resistant cultivars have provided sufficient suppression of TSWV, insecticides were routinely applied solely for managing thrips population and feeding injury without economic justifications. A beat-cup sampling method was evaluated for thrips in peanut, and economic injury levels for F. fusca were established in TSWV resistant cultivars based on the relationships between thrips abundance, feeding injury, and yield. Thrips density exceeded the economic injury levels especially when thrips infestation occurred at early plant ages. Although TSWV resistant cultivars are planted on almost all Southeast US peanut acres, TSWV spread in those cultivars and the impact(s) of virus spread on yield were unclear. Analysis of temporal and spatial TSWV spread in resistant cultivars indicated that substantial secondary spread occurred after mid-season in addition to significant primary spread in early season. Early infection resulted in more severe symptoms than late infection, and significant yield losses to TSWV were observed in plants showing symptoms before 91 days after planting. TSWV infection in peanut leaf and root tissue was commonly confirmed by DAS-ELISA. However, the effect of tissue type on the reliability of DAS-ELISA for TSWV detection has never been evaluated. Using RT-PCR and qRT-PCR as checks, DAS-ELISA overestimated TSWV infection when peanut root tissue was tested. Higher TSWV loads occur in leaf than root tissue and indicate that leaf tissue is a better sink for TSWV and a better tissue type for TSWV detection in peanut. The intensive use of TSWV-resistant cultivars raised concerns about the durability of resistance and changes in TSWV virulence. Evidence was not found to support exertion of selection pressure from resistance in peanut on the five TSWV genes. Some TSWV resistant cultivars differentially affected thrips fitness, which could help maintain the effectiveness of resistance in peanut.