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Abstract
Heat stress may negatively influence the inflammatory responses both systemically and locally in the mammary gland. The objective of the experiment was to evaluate the effect of heat stress on performance and the systemic and mammary inflammatory response with or without mammary inflammation induced by lipopolysaccharide in lactating Holstein cows. Heat stress impaired cow’s performance but did not change the systemic and mammary inflammation in healthy cows. However, following mammary endotoxin challenge, heat stress upregulated the mammary inflammation responses but downregulated the systemic inflammation.