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Abstract
Cerium oxide nanoparticles (CeO2NP) have the unique property of scavenging reactiveoxygen species (ROS), expressed in elevated levels in numerous pathologies. Findings about
cytotoxicity of CeO2NP in the existing literature are contradictory. Many studies found CeO2NP
exhibit low systemic toxicity, whereas other findings suggest that CeO2NP’s exposure to cells
elevates ROS levels under certain conditions leads to cell apoptosis. Also, the phagocytosis of
CeO2NP by cells can result in substantial cytotoxicity. However, CeO2NP encapsulated with
biocompatible polymers shows improved antioxidant and antimicrobial properties with reduced
cytotoxicity, which can be utilized in various drug delivery and tissue engineering applications.
This study aims to assess the cytotoxic effect and evaluate the anti-inflammatory properties of
CeO2NP delivered directly and in poly(ε-caprolactone)- CeO2NP encapsulated state