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Abstract
PURPOSE: The aim of this study is to investigate biochemical markers of CMD risk in children with CP compared to typically developing children, and to examine the relationship of these markers with visceral adiposity and physical activity. METHODS: Forty-one children with CP and 32 typically developing children participated. Blood analysis was completed with serum samples, body composition was measured via dual x-ray absorbtiometry, and physical activity was measured via accelerometry. RESULTS: Children with CP display significantly higher leptin, total cholesterol, LDL-C, and non-HDL-C concentrations (p > 0.05) than controls. Visceral fat mass is significantly related to leptin in both groups (p > 0.05), as well as HOMA-IR in CP (p > 0.05), but not controls (p < 0.05). Physical activity is significantly related to both leptin and HOMA-IR in controls (p > 0.05) but not in CP (p < 0.05) CONCLUSION: Children with CP are at a higher risk of leptin resistance and dyslipidemia. Visceral adiposity and physical activity show differing relationships with CMD risk factors between typically developing children and those with CP.INDEX WORDS: Cerebral palsy, Ectopic fat, Visceral adiposity, Physical activity, Cardiometabolic disease, Leptin, Dyslipidemia