The prevention of thrombosis is crucial to ensure blood-contacting medical device (vascular catheters, vascular stents, etc.) functionality and patient safety. However, despite decades of research in the biomaterials field, thrombosis still remains the most common cause of failure in these devices. When blood is exposed to a foreign surface, thrombosis is triggered via the contact activation pathway, which involves the surface adsorption of plasma proteins and subsequent adhesion/activation of platelet cells. While current antithrombotic surface strategies involve either bioactive or bioinert mechanisms, the prospect of combining both strategies into one material have been overlooked by the research community. Combination of both strategies into one material could result in synergistic improvement and provide a solution to medical device hemocapability. The objective of this dissertation is to develop a novel solution to blood-contacting medical device failure by combining nitric oxide (NO) releasing materials (bioactive) with both impregnated and tethered slippery surfaces (bioinert), characterize the synthesized materials, and then study their respective hemocompatibility. NO-releasing materials have been shown to inhibit platelet activation and thus reduce thrombus formation; however, these materials do nothing to prevent the adsorption of plasma proteins. On the other hand, slippery surfaces increase the thermodynamic requirement needed for foulants to adsorb/adhere, but these surfaces have no direct ability to prevent activation of platelets and have no diffusive effect. Additionally, if a foulant manages to adhere onto a slippery surface, the foulant can be used as an attachment point for cells, thus rendering slippery behavior moot. Therefore, combining both slippery and NO releasing strategies into a single material was expected to result in a decrease of both blood component adsorption/adhesion and platelet activation when compared to controls, which was shown with both types of slippery surfaces.