Knotroot foxtail is a warm-season perennial grass that is problematic in pastures across the Southeastern US. Knotroot foxtail is commonly misidentified as a closely related species, yellow foxtail, leading to further grower confusion and field infestations. An experiment was initiated to investigate the efficacy of fall- and spring-applied herbicides to control knotroot foxtail and promote bermudagrass production. A second experiment was conducted to determine knotroot foxtail’s propagule response to different burial depths. Furthermore, an experiment investigated the biological differences between knotroot foxtail and other common foxtail species. Spring-applied preemergent herbicides were more efficacious than fall-applied herbicides for control of knotroot foxtail. Greenhouse studies indicated that burial depths of 8 cm or more reduced emergence, biomass, and plant heights of all knotroot foxtail propagules. Yellow foxtail had the greatest root biomass from months 1 to 4, until the production of knotroot foxtail rhizomes at month 5.