This research project provides a transcription of Sergei Prokofiev’s (1891-1953) Piano Sonata No. 2 in D Minor, Op. 14 for alto saxophone, violin, cello, and piano. This transcription is a significant contribution to the chamber repertoire for saxophone, especially as it grants access to Prokofiev’s music where little access was available before. The paper explores my transcription choices contextualized by the relevant historical background of Prokofiev’s life and compositional approach in addition to insights offered by the members of the Luminus Piano Trio for whom the transcription was made. Additionally, the project includes a performer’s guide for saxophonists performing chamber music with string players, both in general and more specific to this ensemble and this transcription. I cover topics of balance, blend, tone color, vibrato, and articulation in addition to considering the original performance medium of this sonata and its implication on interpretation.