Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which affects motor neurons within the central nervous system, leading to loss of motor control. This disease currently has no cure, and only five drugs are FDA approved for the treatment of ALS. Research concerning the intercellular communication in ALS motor neurons and surrounding cells as well as the drug delivery capabilities for neurodegenerative diseases through the blood brain barrier (BBB) is imperative. Improving upon specialized platforms and utilizing extracellular vesicles as potential delivery shuttles for therapeutics which target ALS may prove to fill knowledge gaps. Extracellular vesicles, or small membrane-bound particles which are secreted and taken up by most cells in the body, are tenable delivery systems due to their neuroprotective and anti-inflammatory attributes as well as their ability to traverse across the BBB. This research may help improve therapeutic delivery for ALS and further assist in advancing the field of nanomedicine.