Muralism is a popular art trend in many U.S. cities today, making art more accessible to the masses, democratic in expression, and engaging to communities. With this growing popularity, there are still gaps in the knowledge of how mural content, spatial conditions, and community context relate to each other. Although murals are a visual art form, their location, treatment, and integration within a neighborhood can be important to a mural’s reception from its viewers and its surrounding community. Therefore, this study addresses this issue by conducting a case study on one of Atlanta, Georgia’s historic neighborhoods and mural hotspots, Castleberry Hill. In analyzing the relationships between Castleberry Hill’s murals and context, this study found that murals can play a significant role in urban placemaking by providing community representation and engaging public spaces. In better understanding spatial-thematic relationships, muralism can become a more effective tool for placemaking in urban communities.