Nature-based infrastructure (NBI), as an alternative to conventional coastal defense and flood hazard mitigation, can provide resilience and other benefits. For example, oyster reefs act as natural breakwaters while offering additional benefits to the local community, including providing habitat and fishing grounds. The effectiveness of oyster reefs as NBI depends on its growth and survival and is influenced by the surrounding hydrodynamic conditions that affect food flux and sedimentation. A point-based oyster growth model is expanded and linked with a hydrodynamic model to simulate oyster and reef growth in the South Atlantic Bight. The highest live oyster layer heights increase with velocity until a depth-dependent velocity threshold is met, where sediment deposition begins to reduce growth. The potential for wave dissipation (total reef height) is depth-limited with a broader range of favorable locations than consideration for oyster layer height alone.