Files
Abstract
As one of the major challenges worldwide, cancer has been a detrimental health issue for the mainstream public incurring disfunction of surrounding organs or death. Because of the severity of the disease, numerous therapeutic approaches have been proposed this century. And as a part of the treatment, radiation therapy is deemed one of the most powerful and commonly accessible tools. It is non-invasive and can be utilized for almost all types of malignant cancer cell lines and is also reported for treating benign cancers or other diseases such as Kimura and Keloid scars. However, current nanoplatforms for radiation therapy still default the need for tumor eradication, and there are potentially remaining drawbacks that adversely hinder the progress of radiation therapy. One major limitation of conventional radiation therapy is the total dose of radiation that must be taken to fulfill the therapeutic efficacies, and it is always intolerable for most patients receiving high doses of radiation. To overcome this, we tactfully designed and assembled several nanoplatforms that can be applied as radiosensitizing reagents. We evidenced that with the help of those nanoplatforms, we can significantly reduce the dosage for radiation while approaching similar therapeutic efficacies in vitro and in vivo, causing minimal cytotoxicity toward surrounding normal tissues and organs.