The goal of this work was to evaluate the response of cotton to fertigation in southern Georgia, USA. Specific objectives were to conduct a replicated plot field study that evaluated fertigation as an in-season nitrogen application strategy for cotton and to use the DSSAT CSM CROPGRO-Cotton model to evaluate the response of cotton to several combinations of the timing and the amount of nitrogen in fertigation applications. The field study was conducted near Camilla, Georgia between 2018-2021 and found that fertigation resulted in numerically higher yields that were not significantly different from the yields of other in-season fertilization treatments. Simulation results confirmed field study findings that using fertigation to apply in-season nitrogen to cotton results in higher yields than the conventional approach of one liquid side-dress application commonly used in Georgia regardless of the total nitrogen applied. Fertigation also resulted in higher nitrogen use efficiency (NUE) than the conventional approach.