Hemorrhagic disease (HD) is one of the most important viral diseases that affect white-tailed deer (Odocoileus virginianus) in North America. Understanding the impact of climate and habitat on HD activity is important when spatially assessing HD associated risk on the landscape. Recent changes in climate conditions have been linked to increased HD reporting in the eastern United States, but have yet to be described in the Great Plains region. Using annual HD reports from the Great Plains, I analyzed historic and current HD patterns from 1982 to 2020 relative to mean temperature, precipitation, and when the majority of precipitation was received each summer. I also assessed how latitude and longitude temporally changed in the Great Plains from 1982 to 2020. Interaction of mean temperature, precipitation, and timing of precipitation influenced HD reports in the Great Plains, but the importance of landcover varied by state.