Research was conducted from 2020-2022 to address two new potential herbicides for preemergence (PRE) use in peanut and current off-target issues. Cultivar response and weed control in peanut with fluridone was investigated by applying rates ranging from 0 to 673 g ai/ha to seven cultivars including the following: AU-NPL 17; FloRun “331’; GA-06G; GA-16HO: GA-18RU, GA-20VHO; and TifNV-High O/L. GA-16HO showed increased sensitivity to fluridone. Fluridone rates of 673 g ai/ha resulted in yield reductions ranging between 6% to 54%. When applied in a program, PRE applications of fluridone at 112 g ai/ha provided weed control similar to standards. Cultivar response and weed control in peanut with trifludimoxazin was investigated by applying rates ranging from 0 to 75 g ai/ha to the same seven cultivars. All cultivars exhibited acceptable tolerance to trifludimoxazin at rates <75 g ai/ha. When applied in a program, PRE applications of trifludimoxazin at 38 g ai/ha provided weed control similar to standards. Peanut response to imazapyr was investigated by applying 1/100th, 1/10th, 1/5th, and 1X (420 g ai/ha) labeled rates at PRE, 30 days after planting (DAP), and 60 DAP. Results indicated that peanut should not be planted into fields unintentionally treated with imazapyr until rates in soil decline < 1/10thX rate and exposure to off-target rates ≤1/5thX in-season should not result in yield losses. Peanut response to triclopyr was investigated by applying 1/100th, 1/10th, 1/5th, and 1X (840 g ae/ha) labeled rates at PRE, 30 DAP, and 60 DAP. Results indicated that triclopyr is not likely to cause carryover injury to peanut under normal weather conditions and peanut exposed to off-target rates of triclopyr ≤1/10thX in-season should not result in yield losses. Peanut response to glyphosate + dicamba was investigated by applying 1/50th and 1/100th labeled rates at 30 + 60 DAP or 30 + 60 + 90 DAP. Results suggested that if peanut fields are unintentionally exposed to off-target rates ≤1/100thX of glyphosate + dicamba, yields should not be reduced.