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Abstract
The study aimed to evaluate the efficacy of synbiotic supplementation in broilers against necrotic enteritis infection through synbiotic synergistic effect. Total birds were randomly assigned into following experimental groups in subsequent studies: control, challenge, antibiotic, synbiotic, challenge + antibiotic and challenge + synbiotic, and NE was induced by gavaging Eimeria maxima oocysts and Clostridium perfringens. Synbiotic supplementation decreased FI and lesion score, and increased CD4+:CD8+ T cells and NO production in spleen, while during NE challenge, it decreased gut permeability, increased CD4+:CD8+ T cells in cecal tonsil, and decreased IFN-γ expression in jejunum, compared to the control group. Additionally, synbiotic supplementation ameliorated production performances, and strengthened intestinal integrity, improving immune responses, and providing an alternative approach to AGPs. Therefore, synbiotic supplementation could be a potential alternative to replace AGPs in the poultry industry, but its efficacy needs to be improved through blending additional probiotics and prebiotics.