The management of weeds in production agriculture is essential to ensure a quality and prolific crop is produced. Georgia is a diverse state producing nearly 490,000 ha of cotton while simultaneously growing over 33 different vegetable crops each year. Managing weeds in this diverse landscape is complex, thus 9 experiments accounting for 46 individual field and greenhouse studies were conducted fostering better weed control in cotton and vegetables, thereby improving farm sustainability. Farmers rely heavily on PPO-inhibiting herbicides to control Palmer amaranth, the most troublesome pest in the state. Two experiments confirmed a Georgia population of Palmer amaranth exhibited resistance to both preemergence and postemergence applications of this chemistry. To mitigate the spread of this resistant pest and to reduce additional development, integrated weed management approaches were evaluated. A cotton experiment confirmed that a rye cover crop could reduce the emergence of Palmer amaranth by 72%, mitigating exposure to herbicide selection pressure. Additionally, a system of cover crops plus residual herbicides applied at-planting could reduce exposure of Palmer amaranth to postemergence herbicides by 99%. In vegetables, growers using plastic mulch often struggle to control weeds between cropping cycles. Two experiments identified how glyphosate and glufosinate could be used to manage weeds without potentially injuring tomato, cucumber, and squash. Results noted that washing each herbicide from the mulch before planting and ensuring new plants are placed 15 cm away from holes in the mulch will alleviate injury concerns. In vegetables without mulch, data from two experiments led to the creation of a new glyphosate label, helping vegetable growers avoid the residual activity of glyphosate while controlling weeds effectively; both tillage and an increased interval between application and planting were effective options mitigating injury. Cover crops are not commonly used in vegetable production; however, buckwheat may be an ideal species to consider. Its ability to establish and cover the ground quickly offers weed suppression in as little as 35 days. Two studies identified potential herbicides for both control of troublesome weeds in the cover crop, facilitating establishment, while also identifying effective control measures if buckwheat volunteers were to occur in succeeding crops.