Cover crops, in conjunction with crop rotation and conservation tillage, have shown the potential to reduce erosion, increase soil organic matter, and better maintain in-season soil moisture. The main objective of this study was to evaluate three common cover crops/mixtures and determine their effects in a cotton, peanut, and corn rotation on biomass production, soil organic matter, soil moisture, and crop yield. The study site was located in southeast Georgia, and the treatments included a no cover crop control, a cereal rye monoculture, a cereal rye and crimson clover mixture, and a multiple species mixture. Results indicated that incorporating a cover crop into a production system increased soil moisture retention, and a positive relationship was discovered between cover crop biomass and soil organic matter. Year had an effect only on peanut yield compared within year, and cover crop treatment had an effect on corn yield in 2021 and peanut yield in 2022.