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Abstract
Interleukin (IL)-31 has gained attention in the last decade as a major pruritogen across species. Models of induced pruritus have been used to advance the understanding of itch mechanisms and develop novel anti-pruritic medications. Canine models of intravenous IL-31-induced pruritus frequently reproduce itch responses associated with pruritic diseases and conditions such as atopic dermatitis. However, there is a need for better characterizations of both intravenous and intradermal IL-31-induced pruritus canine models. The studies presented here provide an in-depth analysis of the induced pruritic responses in a repeated canine intravenous IL-31 pruritus model and a canine intradermal IL-31 pruritus model. In addition, these studies report on the effects of IL-31 administration on acute and delayed itch responses in canines.