High doses of cottonseed oil (CSO) have exhibited therapeutic effects regarding blood lipids and appetite regulation; however, this resulted in overall dietary fat intake above the recommended levels. The objective of this 4-week outpatient intervention was to determine the impact of enriching diets with 10%, 20%, or 30% of energy from CSO vs. a control (CON) diet on cardiometabolic risk factors including blood lipid metabolism and appetite regulation in individuals at risk of cardiovascular disease (CVD). Participants were randomly assigned into one of three CSO groups: the LOW, MID, or HIGH group, or CON in which participants received 10% energy from an oil mixture. In manuscript #1 (chapter #3), enriching diets with 10%, 20%, and 30% CSO improved fasting blood lipids. In manuscript #2 (chapter #4), 10% and 20% doses improved postprandial subjective appetite. Altogether, 10%, 20%, and 30% doses of CSO improved cardiometabolic health in CVD at-risk adults.
