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Abstract
Clinical psychosis diagnoses depend on patient and informant reports, but such evaluations are susceptible to bias. Diagnoses using laboratory tests are considered more objective, although social disadvantages alter brain functions related to psychosis. I probed relationships of SES, race/ethnicity, and genetic background to 11 integrated laboratory bio-factors that are associated with psychosis and distinguish B-SNIP psychosis Biotypes. A series of analyses evaluated relationships of social factors and ancestry-related genetic background on those bio-factors: (i) canonical correlation revealed that SES and race (a social construct) are moderately associated (r2=.305) with cognitive performance and measures of brain physiology (prominently ERP magnitudes); genetic background neither significantly added to nor altered the structure of those associations; (ii) regression models illustrated that cognitive performance, intrinsic brain activity, and ERP magnitudes are substantially to modestly predicted by SES/race/genetic background, with SES/race accounting for the most variance on cognitive performance (approximately 25%); (iii) regardless of including SES/race in differential diagnosis models, group differences between psychosis Biotypes were largely (85%) preserved on bio-factor scores. These outcomes illustrate that social factors are associated with psychosis-related laboratory tests. Nevertheless, SES/race did not substantially modify differential diagnosis of psychosis Biotypes. Using laboratory tests for psychosis differential diagnosis may facilitate the usefulness of stratification approaches, aid investigations of psychosis neurobiology, and improve treatment selections for all persons suffering with idiopathic psychosis.