Healthcare-associated infections are a major hindrance in the healthcare industry, increasing hospital costs, hospital stay, and mortality rates. Two of the most common HAIs are catheter-associated urinary tract infections (CAUTIs) and ventilator-associated pneumonia (VAP), related to urinary catheters and endotracheal tubes, respectively. Nitric oxide (NO), an endogenous gas released from the endothelium, is proven to be a strong bactericidal agent. Nitric oxide can be incorporated into biomaterials using NO donors for localized release by a variety of methods. These studies will focus on solvent swelling to incorporate the NO donor S-nitroso-N-acetylpenicillamine. The studies herein examine the effects of (i) solvent swelling to create a synergistic combination of NO with liquid-infused properties for the reduction of CAUTIs and (ii) solvent swelling with endotracheal tubes for the use of NO to reduce the occurrence of VAP.