Although prior research has recognized synergistic relationships between the life domains that aggregate to form an individual's overall well-being, extant research focuses on how well-being in a single life domain contributes to overall well-being or a one-to-one synergy between two domains without regard to overall well-being. Such work represents the current, siloed approach to exploring overall well-being or life domains, considering only pieces of the person rather than the whole person. Little is known about the nature of the synergies between the life domain and how these synergies interact and contribute to an individual's overall well-being. This dissertation provides a theory, framework, and way of working to facilitate the development of a comprehensive body of literature that could, in the future, offer a complete understanding of how the life domains interact to produce well-being. The Theory of Whole Person Well-being is developed to inform a three-part framework for building a body of knowledge to provide a greater understanding of the synergies among and between the life domains. Across three studies, I then demonstrate the application of the theoretically derived framework as a starting point for shifting from a siloed, problem-centered approach to a holistic, whole-person approach to well-being. In addition to implementing and demonstrating the framework across the three studies, the results of each study also provide valuable insights into the nature of specific synergies present in the life domains, specifically those that involve the financial domain. Transformative services research and practice could benefit from research that considers the whole person and how the various life domains interact to produce an individual's well-being. Understanding the synergies among the life domains in how services are formed will allow for a greater impact in maintaining and improving well-being.