Research was conducted to evaluate herbicide tolerance and efficacy across Georgia agronomic production systems. These issues include pink purslane control with postemergence (POST) herbicides, grain sorghum response to herbicide carryover from watermelon production, peanut cultivar response to POST applications of chlorimuron, and peanut response to delayed timings of fluridone and trifludimoxazin.Pink purslane control with POST herbicides commonly used in agronomic crops was investigated both in greenhouse and in-field experiments. Results from the greenhouse screening indicated 13 of the 21 POST herbicides provided ≥ 80% above-ground biomass reductions. In-field experiments indicated that pink purslane above-ground biomass reductions at 14 days after treatment were only ≥ 70% for 3 of the 13 herbicides including atrazine at 1682 g ai ha-1 (79%), glufosinate at 656 g ai ha-1 (70%), and lactofen at 219 g ai ha-1 (83%). Grain sorghum tolerance to applications of fomesafen and terbacil was investigated by applying five rates of fomesafen (35, 70, 140, 210, 280 g ai ha-1) or four rates of terbacil (3.5, 7.0, 10.5, 14.0 g ai ha-1) to the soil 90-100 days before planting (DBP). Results indicated in 2019 fomesafen caused significant sorghum injury, and yield reductions of at least 16% when rates were ≥ 210 g ai ha-1. In 4 of the 5 years of studies, sorghum had sufficient tolerance to fomesafen. Terbacil had no effect on grain sorghum. Peanut cultivar response to chlorimuron, and incidence of tomato spotted wilt virus (TSWV) was investigated by applying chlorimuron at 65, 75, and 90 days after planting (DAP). Peanut yields were not significantly reduced for all cultivars and timings except for Georgia-16HO. Yield losses for Georgia-16HO were 17%, on average, when chlorimuron was applied at 75 DAP. Results suggest that these new cultivars, excluding Georgia-16HO, are sufficiently tolerant to POST applications of chlorimuron. Peanut response to fluridone and trifludimoxazin was investigated by applying 1X labeled rates at 1, 3, 5, and 7 DAP. Although early season stunting was observed, by 80 DAP there was no effect on peanut height and width. Peanut yields were not reduced by any timing of fluridone or trifludimoxazin.