Development of Methane-Tris(diazeniumdiolate) Nitric Oxide Donor for Medical Device-Associated Infections

Long-term indwelling catheters are prone to catheter-related bloodstream infections (CRBSIs). The approved treatment of CRBSIs is to remove the catheter, but a preventative measure used is antibiotic lock therapy, which involves instilling an antibiotic solution in the lumen of the catheter. However, these antibiotic lock solutions provide no protection to the outer surface of the catheter, where most infections occur. Due to this major drawback, a recent advancement is using Nitric Oxide (NO) releasing lock solutions, which provide extraluminal protection as NO gas can diffuse through the catheter walls. This thesis focuses on the development of a new NO donor with increased NO production and stability in physiological environments, aiming to provide prevention as well as treatment against CRBSIs.