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Abstract
Atopic dermatitis (AD) is a chronic pruritic and inflammatory skin disease with high prevalence that affects humans and dogs, with a majority of cases demonstrating IgE antibodies directed at environmental allergens. Canine and human spontaneous AD are often associated with diminished quality of life and an economic burden. Current murine models of AD lack high gene homology to human AD and have limited predictive power. The very near identical AD clinical phenotype between humans and dogs allows a unique opportunity to investigate both itch and inflammation in canine models for potential novel drug development benefiting one or both species. Using canine AD-like modeling and RNA sequencing techniques, we will demonstrate high homology between immune and pruritogenic pathways in canines and human spontaneous AD from human study cohorts. These observations will reveal that canine AD recapitulates molecular pathways in human AD and that those pathways are inducible in canine AD-like models for future investigation and therapeutic development.