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Abstract

Nintedanib Esylate is an on market gel capsule oral dosage therapeutic for idiopathic pulmonary fibrosis and is classified as a BCS class II or IV drug due to its low solubility. The purpose of this study is to first understand the gel-point of this therapeutic this is done through a series of experiments in aqueous conditions to gain an understanding of how the material interacts while in solution. The Gelation phenomenon is further understood to be the formation of Lyotropic Liquid Crystals seen through Optical Microscopy. Further characterization of these gels such as rheology, and 1H-NMR are used to understand the mechanical properties of the material as well as the locations of electrostatic interactions that create the mechanism for the development of a supramolecular structure in water.

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