Video games have become an integral part of our lives. Studying the brains responses tovideo games becomes more and more important for many aspects of video games. This thesisdescribes our effort in using neuroimaging techniques and computational approaches to study thebrains responses to gameplay-based stimuli. We have designed a car driving video game andcarried out the functional magnetic resonance imaging (fMRI) of the human subject during the experiment. We present fiber centered Granger causality analysis (GCA) studies on fMRI datasets in order to elucidate the functional dynamics of GCA. Precisely, we first acquired the corpus callosum fibers,which are used as a structural communication channel between the left and right hemispheres of the brain. Then, we extract the fMRI BOLD signals from the two endsof a white matter fiber derived from diffusion tensor imaging (DTI) data, and examine theirGranger causalities based on fMRI data. Our experimental results show reasonably goodcorrespondence between the car driving directions and the Granger causalities in the fMRI data.Our studies revealed meaningful functional brain dynamics driven by the gameplay.