Mankind fantasized about space travel and living on other worlds long before technology allowed it to get there. Now that the concept of a permanent presence in space is a more viable option, it has become critical to plan not just the way to get there, but also how to grow and sustain successful and thriving life upon arrival. The organic ideals of Metabolism may offer that solution. The Metabolism movement was created when a group of young urbanists proposed a transformative paradigm shift from conventional modernist ideals toward a biological Utopianism. This study examines and considers the key design principles of Metabolism and analyzes how those principles can be applicable when planning for space colonization, and illustrates how an idea, once considered extreme, can act as a substantial foundation on which to build mankinds future.