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Abstract
Kynureninase is a pyridoxal-5-phosphate (PLP) dependent enzyme in the kynureninemetabolic pathway of L-tryptophan in animals and bacteria. In mammals, this pathwayprovides a de novo synthesis of NAD(P)+ . The mammalian kynureninase catalyses thehydrolytic cleavage of 3-hydroxy-L-kynurenine to 3-hydroxyanthranilic acid and Lalanine.One of the metabolites in this pathway is quinolininc acid. Quinolinic acid is aneurotoxin if produced in excess of its biosynthetic requirement. Potent inhibitors of thisenzyme are required as drug targets for several neurological disorders and otherdiseases including Alzhemiers, AIDS related dementia and Huntingtons disease. In thecurrent work, potent inhibitors and substrates for both human and bacterialkynureninase have been synthesized and kinetically evaluated for their enzymaticactivity.