This study investigates the socioeconomic activity of the United States Department of State, including American firms, in French Mandate Syria. Experiencing difficulties securing large public works contracts in the Mandates insular and French-dominated economy, an American critique of colonial capitalism ultimately emerges. Analysis of the colonial press, Consulate reports, and high-level correspondence between the State Department and actors on the ground reveals the corruption of colonial institutions. Exploring the role of financial capital in promoting the marriage of private interests with colonial government also highlights the degradation of the French Mandates custodial role in Syria, including the failure of the colonial government to safeguard the public welfare. Ultimately, this study debunks the long-held contention that the United States remained isolationist until the outbreak of the Second World War.